The Sixteenth-seeded Siena Saints face the top-seeded Duke Blue Devils within the first spherical of the 2026 NCAA Tournament East Region on Thursday. Siena is coming off a 64-54 win over Merrimack within the MAAC Tournament ultimate on March 10, whereas Duke defeated Virginia 74-70 to win the ACC Tournament ultimate on Saturday. The Saints (23-11), who’ve received 4 in a row, positioned third within the MAAC regular-season standings with a 13-7 mark. The Blue Devils (32-2), who’ve received 11 straight, received the ACC regular-season title at 17-1 in league play. Duke can be with out Caleb Foster (foot) and Patrick Ngongba II (foot).
Tipoff from Bon Secours Wellness Arena in Greenville, S.C., is ready for two:50 p.m. ET. Duke leads the all-time sequence 1-0, incomes a 92-74 win in 2015. The Blue Devils are 28.5-point favorites within the newest Siena vs. Duke odds, whereas the over/underneath for complete factors scored is 136.5. Duke is at -33333 on the cash line (threat $33,333 to win $100). Before making any Duke vs. Siena picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.
The SportsLine Projection Model simulates each school basketball sport 10,000 instances. It entered the 2026 NCAA Tournament on a scorching 11-1 run on its top-rated over/underneath school basketball picks relationship again to final season, and is on a 28-22 run on top-rated CBB facet picks. Anyone following its school basketball betting recommendation at sportsbooks and on betting apps might have seen robust returns.
Now, the mannequin has simulated Siena vs. Duke 10,000 instances and simply revealed its coveted males’s school basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are a number of men’s college basketball odds and males’s school basketball betting strains for Duke vs. Siena:
Siena vs. Duke unfold: | Duke -28.5 |
Siena vs. Duke over/underneath: | 136.5 factors |
Siena vs. Duke cash line: | Siena +5000, Duke -33333 |
Siena vs. Duke picks: | See picks at SportsLine |
Siena vs. Duke TV: | CBS |
Top Siena vs. Duke predictions
After 10,000 simulations of Siena vs. Duke, SportsLine’s mannequin is going Over on the entire (136.5 factors). The Over hit within the 2015 assembly between the groups. The Over has additionally hit in two of the final three Duke video games. Siena is 6-4 towards the unfold in its final 10 video games. Duke, in the meantime, is 6-3 ATS in its final 9.
The mannequin tasks the Saints to have two gamers rating 11.6 factors or extra, together with Gavin Doty, who’s projected to attain 14.8 factors. The Blue Devils are projected to have three gamers rating 11.5 factors or extra, led by Cameron Boozer, who’s projected to attain 25.7 factors. The mannequin is projecting 145 mixed factors as the entire is surpassed in 74.3% of simulations.
How to make Duke vs. Siena picks
The mannequin additionally says one facet of the unfold hits almost 60% of the time. You can only see that pick at SportsLine.
So who wins Duke vs. Siena, and which facet of the unfold hits in almost 60% of simulations? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has simulated this game 10,000 times, and discover out.
